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Why Alnylam Pharmaceuticals (ALNY) Stock Is Up Today

Investivoq PriceTracker

Alnylam Pharmaceuticals (ALNY) is up 6.9% today. Here is some analysis on what might have caused this price movement.

Analysis: The most likely driver is renewed investor optimism after Alnylam shared strong long-term HELIOS-B data for AMVUTTRA in ATTR-CM, which reinforced the case for durable cardiovascular benefit and the value of earlier treatment. The move may also reflect improving sentiment after management recently reiterated full-year 2026 guidance and authorized a $1 billion share repurchase program, giving investors another signal of confidence following the post-earnings volatility earlier this month.

Details:

  • Alnylam said new five-year HELIOS-B data showed patients treated continuously with AMVUTTRA had lower rates of all-cause mortality and recurrent cardiovascular events than those who started treatment later.
  • The same update highlighted better preserved quality of life and more stable cardiac biomarkers over time, which can strengthen the commercial outlook for AMVUTTRA in ATTR-CM.
  • In its recent third-quarter update, Alnylam reiterated 2026 guidance, including total net product revenue of $4.7 billion to $5.1 billion and TTR franchise revenue of $4.2 billion to $4.5 billion.
  • The board also authorized a $1 billion stock repurchase program, with about $500 million expected by the end of 2026, signaling that the company believes the shares are undervalued.

    • Sources:

    Alnylam, SEC, Google Finance

    Disclaimer: This price movement analysis was generated with the help of AI. Please double-check the information provided for mistakes.

    $ALNY Insider Trading Activity

    ALNY Insider Trades

    $ALNY insiders have traded $ALNY stock on the open market 8 times in the past 6 months. Of those trades, 2 have been purchases and 6 have been sales.

    Here’s a breakdown of recent trading of $ALNY stock by insiders over the last 6 months:

    • DAVID E I PYOTT has made 0 purchases and 5 sales selling 3,830 shares for an estimated $1,145,852.
    • BRYAN SUPRAN (EVP, CLO and Secretary) sold 1,758 shares for an estimated $398,855
    • AMY W SCHULMAN purchased 1,910 shares for an estimated $299,526
    • CHARLES ELLIOTT SIGAL purchased 1,600 shares for an estimated $243,600

    To track insider transactions, check out Investivoq's insider trading dashboard. You can access data on insider stock transactions through the Investivoq API insider transaction endpoint.

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    $ALNY Hedge Fund Activity

    We have seen 393 institutional investors add shares of $ALNY stock to their portfolio, and 423 decrease their positions in their most recent quarter.

    Here are some of the largest recent moves:

    • T. ROWE PRICE INVESTMENT MANAGEMENT, INC. added 4,490,826 shares (+390.0%) to their portfolio in Q2 2026, for an estimated $1,351,873,350
    • BAILLIE GIFFORD & CO added 3,052,580 shares (+125.1%) to their portfolio in Q3 2026, for an estimated $753,193,589
    • CAPITAL WORLD INVESTORS added 2,674,998 shares (+24.0%) to their portfolio in Q3 2026, for an estimated $660,029,006
    • FMR LLC removed 2,401,464 shares (-16.0%) from their portfolio in Q3 2026, for an estimated $592,537,227
    • CAPITAL RESEARCH GLOBAL INVESTORS added 1,190,206 shares (+12.2%) to their portfolio in Q3 2026, for an estimated $293,671,428
    • JPMORGAN CHASE & CO removed 953,332 shares (-35.6%) from their portfolio in Q3 2026, for an estimated $235,225,137
    • AMERICAN CENTURY COMPANIES INC removed 843,817 shares (-45.5%) from their portfolio in Q3 2026, for an estimated $208,203,406

    To track hedge funds' stock portfolios, check out Investivoq's institutional holdings dashboard. You can access data on hedge funds moves and 13F filings through the Investivoq API 13F endpoint.

    $ALNY Congressional Stock Trading

    Members of Congress have traded $ALNY stock 1 times in the past 6 months. Of those trades, 0 have been purchases and 1 have been sales.

    Here’s a breakdown of recent trading of $ALNY stock by members of Congress over the last 6 months:

    • SENATOR CORY A. BOOKER sold up to $15,000 on 08/11.

    To track congressional stock trading, check out Investivoq's congressional trading dashboard. You can access data on congressional stock trades through the Investivoq API Congress trades endpoint.

    $ALNY Analyst Ratings

    Wall Street analysts have issued reports on $ALNY in the last several months. We have seen 1 firms issue buy ratings on the stock, and 0 firms issue sell ratings.

    Here are some recent analyst ratings:

    • HC Wainwright & Co. issued a "Buy" rating on 06/29/2026

    To track analyst ratings and price targets for $ALNY, check out Investivoq's $ALNY forecast page.

    $ALNY Price Targets

    Multiple analysts have issued price targets for $ALNY recently. We have seen 2 analysts offer price targets for $ALNY in the last 6 months, with a median target of $425.0.

    Here are some recent targets:

    • Patrick R. Trucchio from HC Wainwright & Co. set a target price of $470.0 on 06/29/2026
    • Eric Joseph from Citigroup set a target price of $380.0 on 05/19/2026

    This article is not financial advice. See Investivoq's disclaimers for more information. Note that there may be inaccuracies due to mistakes in ticker-mapping, and other anomalies.